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Neuroscience QuarterlyAddiction and Depression are mental health disorders with biological origins in the brain. They are also public health challenges with serious consequences. Globally, depression is the leading cause of disability, affecting up to 15 percent of the population, while addiction’s devastating effects have made headlines across the globe and especially in the United States in relation to the opioid crisis. Unfortunately, today’s treatments for addiction and depression are inadequate for many patients. Continued basic research is needed in order to better understand these disorders and formulate more effective therapeutics.